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Quorum Sensing Inhibition by a Novel Pyrrolobenzodiazepine Analog

Erin Shay, Jairius Mayweather, Joel Annor-Gyamfi, § Abbas Shilabin, § Dobrusia Bialonska

Department of Biology, University of North Georgia, Dahlonega, GA, 30597

§ Department of Chemistry, East Tennessee State University, Johnson City, TN, 37614

Bacteria can communicate with each other via quorum sensing (QS). This communication allows bacteria to determine bacterial density in a given area and then change their gene expression when a large enough group is detected. Many bacterial activities have been shown to be QS-regulated including toxin production, biofilm formation, and light production. If the process of QS can be interrupted it is possible that bacteria could be rendered less pathogenic; therefore, there has been an increased interest in discovery of novel quorum sensing inhibitors (QSI). The bacterium Chromobacterium violaceum serves as a model organism, because it produces a purple pigment if QS is reached or remains colorless if QS is inhibited. In this study, we used a disk diffusion assay to evaluate QS inhibitory activity of several pyrrolobenzodiazepine (PBD) analogs. PBDs are produced by soil actinomycetes bacteria. One of the studied PBD derivatives showed a promising quorum quenching activity, which hasn’t been reported for this class of molecules before.


This is a metadata-only record.



  • Subject
    • Biology

  • Institution
    • Dahlonega

  • Event location
    • Nesbitt 3110

  • Event date
    • 25 March 2016

  • Date submitted

    18 July 2022

  • Additional information
    • Acknowledgements:

      Dr. Dobrusia Bialonska