Using X-Ray Fluorescence (XRF) equipment to measure the concentration of iron in the spleens of Methamphetamine (METH) treated mice C57BL6/J

Abstract

X-Ray Fluorescence (XRF) is the physical process of element detection in a variety of materials. Currently, a technique is being developed which will allow the XRF equipment to measure the concentration of iron in the spleens of mice. One physiological consequence of methamphetamine (METH) overexposure is the accumulation of iron in the spleen. This technique will provide a simple method to quantitatively measure the concentrations of iron in a small sample of spleen tissue as well as provide a new application to the XRF equipment. This presentation will discuss the preliminary results in developing a simple method of quantitatively measuring the relative difference in the concentration of iron in spleens from METH infected mice and spleens from uninfected mice.